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Complications of Untreated SIBO If left untreated, SIBO can lead to significant complications, including: Nutrient deficiencies (vitamin B12, iron, magnesium, zinc, and fat-soluble vitamins) Weight loss and malnutrition Leaky gut (increased intestinal permeability) Systemic inflammation Mood disturbances (due to gut-brain axis disruption) Worsening of autoimmune or chronic disease The longer SIBO persists, the more damage it can do—not just to your gut, but to your overall health